%0 Journal Article
%T Endostatin-Encapsulated N-Succinyl-Chitosan Nanoparticles Inhabited the Growth of MCF-7 Cell
%A Yanrong Fan
%A Ye Li
%A Xuefei Xia
%J Open Access Library Journal
%V 2
%N 12
%P 1-9
%@ 2333-9721
%D 2015
%I Open Access Library
%R 10.4236/oalib.1102083
%X A simple method was developed to synthesize the N-succinyl-chitosan (NSC)
successfully. NSC was characterized by FTIR, <sup>1</sup>H NMR and element
analysis. The NSC can form nanoparticles with TPP through electrostatic interaction.
The morphology, particle size and zeta potential of the nanoparticle were
investigated and showed a 100 - 200 nm in diameter with a positive potential
9.99 mv. The encapsulation efficiency of
NSC-ES-NPs was 94.76 ¡À 0.05. The <i>in vitro </i>cell culture indicates that NSC has non-toxicity and cell-compatibility.
NSC-ES-NPs show antitumor activity against MCF-7 cell. Our results demonstrate
that NSC has great potential in the drug controlled release delivery.
%K N-Succinyl-Chitosan
%K Nanoparticle
%K Endostatin
%U http://www.oalib.com/paper/3152199