%0 Journal Article
%T The Comparison of Clinical and Biochemical Outcomes in Off-Pump and Conventional Coronary Artery Bypass Grafting Surgery
%A Z. Temizturk
%A D. Azboy
%A K. Karapinar
%A I. Ince
%A M. Bozguney
%A S. Sahinalp
%A O. Ersoy
%A A. Bulut
%A E. Yucel
%J Open Access Library Journal
%V 2
%N 8
%P 1-8
%@ 2333-9721
%D 2015
%I Open Access Library
%R 10.4236/oalib.1101799
%X Objective: There is no common concencus the clinical
results of coronary artery bypass grafting (CABG) surgery patients who
underwent off-pump or conventional techniques. Our aim of this study was to compare
the changes of myocardial functions, patients¡¯ clinical results, biochemical
marker release during surgery and postoperatively in On- and Off-Pump CABG
surgery. Method: A consecutive series of 50 coronary artery disease (CAD)
patients who underwent elective CABG surgery included for this study. The
patients were divided into two groups (Group 1, N = 25 and group 2, N = 25).
Demographic data including the patients¡¯ age, gender, body mass index (BMI),
diseased coronary artery numbers, LVEF were similar. Postoperative red package blood cell, fresh frozen
plasma, and thrombocyte requirements were high in On-Pump group (<i>p</i> < 0.05). But there was not any significant
difference when compared the number of unexpected surgery because of
mediastinal bleeding after operations in both groups. Preoperative and postoperative N-Terminal Pro-Brain
Natriuretic Peptide (NT-proBNP), cardiac Troponin-I (cTnI) levels during and
after surgery, and left ventricular ejection fractions (LVEF) prior to
discharge from hospital were compared. Results:
There were no statistical significancy when compared postoperative mortality
and morbidity. The operations time was low in off-pump group (<i>p</i> <
0.05). The NT-proBNP levels were similar in both groups (<i>p</i> > 0.05). However, cTnI levels were
significantly higher in the on-pump group (<i>p</i> = 0.0001). Postoperative LVEF decreased significantly in both groups when
compared to preoperative echocardiography examinations (<i>p</i> = 0.001). But the changes of postoperative LVEFs in both groups were not statistical significant (<i>p</i> > 0.05). Conclusion: Our study results indicated that cardiac
enzyme release was high after On-Pump CABG surgery. However, LVEF decreased in both techniques. There were some advantages of
OPCAB operations such as decrease of inflammatory responses and angina pectoris
incidence due to extracorporeal circulation; however, these techniques did not
affect postoperative mortality and morbidity. Therefore, in selected cases to
provide longer operation time, Off-Pump CABG could be used but it has no
superiority over On-Pump CABG surgery.
%K Coronary Artery Bypass Grafting
%K On-Pump
%K Off-Pump
%K Left Ventricular Functions
%U http://www.oalib.com/paper/3149128