%0 Journal Article
%T Synthesis and Cytotoxicity of Heterocyclic Compounds Derived from Cyclohexane-1,3-Dione
%A Mohamed A. Shaaban
%A Mona M. Kamel
%A Yara R. Milad
%J Open Access Library Journal
%V 1
%N 9
%P 1-16
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1101115
%X Cyclohexane-1,3-dione
(1) was used as a template to develop new anticancer compounds. The ring modification
of compound 1occurred through its reaction with either aromaticaldehydes or benzenediazonium
chloride to produce the corresponding products. The latter compounds underwenttheterocyclization
reactions through the reaction with elemental sulfur and some active methylene
reagents to produce tetrahydrobenzo[<i>b</i>]thiophene
derivatives. The reaction of compound 1 with elemental sulfur and phenylisothiocyanategave
the tetrahydrobenzo[<i>d</i>]thiazole derivative.
The cytotoxicity of the newly synthesized products against human cancer and normal
cell lines was evaluated. Some compounds showed high cytotoxicity against
cancer cell lines. The results showed that compounds 3b, 5c, 7b, 10b, 12, 14b,
16, 18b, 19b, 20b, 21 and 24 showed the highest cytotoxicity. Moreover, the
toxicity of twelve active compounds were measured.
%K Cyclohexane-1
%K 3-Dione
%K Thiophene
%K Thiazole
%K Pyridazine
%K Cytotoxicity
%U http://www.oalib.com/paper/3129834