%0 Journal Article
%T New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity
%A Rafat M. Mohareb
%A Sherif M. Sherif
%A Wagnat W. Wardakhan
%A Amr S. Abouzied
%J Open Access Library Journal
%V 1
%N 8
%P 1-16
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1101089
%X Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or
ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f.
The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-<i>b</i>]pyridine, thieno[2,3-<i>c</i>]pyrimidine and coumarin derivatives
was studied. The anti-tumor evaluation of the newly synthesized compounds
against the three human tumor cells lines namely breast adenocarcinoma (MCF-7),
non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that
compounds 8a, 8b and 14 exhibit higher inhibitory effects towards the three
tumor cell lines than the positive control doxorubicin.
%K Acetoaceanilide
%K Thiophene
%K Anti-Tumor
%K Docking
%U http://www.oalib.com/paper/3129353