%0 Journal Article
%T Molecular Signature of Influenza A
%A Raghavendra Krishnappa
%A Rajendran Paramasivam
%J Open Access Library Journal
%V 1
%N 7
%P 1-7
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100979
%X This research work provides comprehensive meaningful
valuable findings from NCBI database for researches to analyze entries of H1N1 strains
aiming to design genomic region-specific markers and also for screening the region-specific
subtypes. Influenza
A viruses are divided into subtypes, based on the nature of their surface glycoproteins,
HA and NA. There are 16 different HAs and nine NAs which are distinguishable
serologically, and we have sincerely dug NCBI database. We have found 7651
entries of H1N1 strains starting from the year 1918 till 2011 in the NCBI
database, most recent entries from past few years includes, 1720 entries in the
year 2008, 9112 entries in 2009, 1132 entries in 2010, 733 entries in 2011. Recent
past few years has seen a rapid growth in high-throughput technology which has
resulted in more entries accounting for 71.93% of the total entries in NCBI
H1N1 Genome Database, in that, year 2009 which resulted in pandemic holds
51.62% share of the total H1N1 genome entries. 2009 entries were separated
based on region of occurrence which resulted in 89 different regions. The above
separation helps the researches for designing region-specific markers for
screening the region-specific subtypes. Apart from that researches
also get other key information like year of pandemic, subtypes responsible for
pandemic, genes and virulence activity, genes functionality which can be used
for genotyping.
%K NCBI
%K Hemagglutinin (HA)
%K Neuraminidase (NA)
%K Subtypes
%K Primers
%K PCR and Molecular Screening
%U http://www.oalib.com/paper/3113693