%0 Journal Article
%T The Paradoxes of EMT Theory in Carcinoma Metastasis
%A Mingyang Li
%J Open Access Library Journal
%V 1
%N 6
%P 1-4
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100937
%X The epithelial-to-mesenchymal transition (EMT) is a process where epithelial cells
with polarity and tight junction change into mesenchymal cells without polarity
and intercellular adhesion to obtain an ability of invasion and metastasis. Interest in the EMT theory has grown exponentially in the last several
years and it has become one of the hottest subjects in cancer research.
However, there is no convincing evidence of EMT in human tumor and numerous
paradoxes do exist about EMT theory from molecular
researches to clinical observations. Thus, the so-called EMT in carcinoma
metastasis is probably a pseudo concept at present.
%K Carcinoma Metastasis
%K Epithelial-to-Mesenchymal Transition (EMT)
%K Paradoxes
%U http://www.oalib.com/paper/3104655