%0 Journal Article
%T Genetic Polymorphisms at TNF Microsatellites from the HLA CLASS III Region in a South Tunisian Population
%A Nadia Mahfoudh
%A Arwa Kamoun
%A Lilia Gaddour
%A Faiza Hakim
%A Hafedh Makni
%J Open Access Library Journal
%V 1
%N 6
%P 1-6
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100929
%X To evaluate the tumor necrosis factor (TNF) a-b-c microsatellite
polymorphism in South Tunisia, we studied 123 healthy unrelated controls from
South Tunisia. TNF microsatellite alleles were typed using genomic DNA amplified
with specific primers. Statistical analyses were performed using ARLEQUIN software. The TNFa6 (18.9%),
TNFa2 (16.4%), TNFb5 (41.9%), and TNFc1 (68.7%) were the most frequent alleles in our population, whereas the TNFa8 and
TNFb2 were the least frequent alleles. To investigate the association among the
three microsatellites, a detailed haplotype analysis was performed. 236 different haplotypes were possible but there was only 15 haplotypes
had frequencies greater than 2%. In our population the most frequent haplotype
TNFcab were ¡°TNFc1a6b5¡± (10.03%). These results may be informative for studies
of the associations of individual TNF region markers with secretion levels,
immunity, and disease.
%K TNF
%K Microsatellite
%K Haplotype
%K Population
%U http://www.oalib.com/paper/3104645