%0 Journal Article %T A Search for Factors that Predict the Efficacy of Viscosupplementation in Knee Osteoarthritis %A R. Michelle Koolaee %A H. Ralph Schumacher %A Michael Shoemaker %A Sarah Mooar %A Sally Pullman-Mooar %J Open Access Library Journal %V 1 %N 5 %P 1-8 %@ 2333-9721 %D 2014 %I Open Access Library %R 10.4236/oalib.1100700 %X

Objective: Previous research demonstrates inconsistent effects of hyaluronate (HA) viscosupplementation on patients with knee osteoarthritis (OA). The purpose of this study was to evaluate factors that predict clinical response to a single intra-articular injection of Hylan GF-20. Methods: This was an observational study of 55 patients with knee OA, scheduled to receive intra-articular injections of Hylan GF-20. These patients met the institution¡¯s guidelines for use of viscosupplementation, which entails failure/intolerance of medical management of OA. At baseline, patients completed a series of questionnaires, including the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Patient Health Questionnaire (PHQ-9) depression score. Questionnaires were repeated at three months post-injection. A clinical responder was someone with a change in KOOS score which exceeded the mean minimal detectable change (MDC) values calculated based on test-retest reliability coefficients reported in four prior studies. Hypothesized predictors of response included PHQ-9 score, baseline visual analog scale (VAS) pain score, age, body mass index (BMI), and Kellgren score. Results: There were 35 responders and 20 non-responders. There were no statistically significant differences between responders and non-responders for any of the primary predictors. There were no differences for secondary predictors, including history of knee injury or smoking, prior HA injection, prior intra-articular corticosteroid injection, or location of OA. There was a moderate negative correlation between age and change in total KOOS score (r = ¨D0.32, p = 0.01). Conclusions: Our research did not confirm previous predictors of response to hyaluronate injections, and highlighted the need for prospective studies in order to answer this question.

%K Hyaluronic Acid %K Viscosupplementation %K Osteoarthritis %K Knee Osteoarthritis %K Efficacy %K Hyaluronate %U http://www.oalib.com/paper/3096473