%0 Journal Article
%T Simple UV Spectrophotometric Assay of Metronidazole
%A Safila Naveed
%A Fatima Qamar
%J Open Access Library Journal
%V 1
%N 6
%P 1-4
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100615
%X Metronidazole is a derivative of benzimidazole. It
is being used widely for the treatment of amoebiasis. An efficient, simple and
least time consuming spectrophotometric method for the assay of metronidazole
has been developed. Comparison of assay of three different brands of metroni-da- zole has also been available in public medical stores of Karachi, Pakistan. The assay is based on
the ultraviolet UV absorbance maxima at about 340 nm wavelength of
metronidazole using water as solvent. A sample of drug was dissolved in water
to produce a solution containing metronidazole. Similarly, a sample of ground
tablets of different brands were dissolved in water and various dilutions were
made. The absorbance of sample preparation was measured at 340 nm against the
solvent blank and the assay was determined by comparing with the absorbance of
available brand. The method can be applied for the routine QC quantitation of
metronidazole in tablet formulation actively.
%K Metronidazole
%K Assay
%K UV Spectrophotometry
%U http://www.oalib.com/paper/3065217