%0 Journal Article
%T A HILIC Mechanism Discussion for the Retention of HP-<i>¦Â</i>-CD
%A Jianqiang Wei
%A Hui Wang
%A Song Wu
%J Open Access Library Journal
%V 1
%N 4
%P 1-6
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100435
%X A hydrophilic interaction liquid chromatography (HILIC) method coupled
with a refractive index (RI) detector was developed for the determination of
hydroxypropyl-<i>¦Â</i>-cyclodextrin (HP-<i>¦Â</i>-CD). This HILIC method used simple
acetonitrile/water (80/20, v/v) as the mobile phase to provide sufficient
retention for HP-<i>¦Â</i>-CD. The method was
found to be specific without interference from the other constituents in
pharmaceutics. The method was also validated for linearity and accuracy of the
drug sample. The effects of various parameters, such as acetonitrile content,
mobile phase pH, and column temperature on HILIC analysis were investigated.
Furthermore, the retention mechanism was assessed by the evaluation of the
common chromatographic parameters.
%K Hydroxypropyl-¦Â-Cyclodextrin
%K Quantitative Analysis
%K Pinocembrin
%K HILIC
%U http://www.oalib.com/paper/3052673