Seroprevalence Virus in Human Immunodeficiency Sickle Cell Anemia Duffy-46C/C in Democratic Republic of Congo—Case of the City of Kinshasa and Lubumbashi
Homozygous sickle cell disease undergoes multiple blood
transfusions during their life because of chronic hemolytic anemia associated
with their condition and the risk of infection is most convincing, for example
vis-à-vis certain viruses such as HIV, the virus hepatitis.This study
aims to determine the HIV seroprevalence among sickle cell anemia Duffy-46C/C. This
is a cross-sectional descriptive study to determine HIV seroprevalence in Duffy-46C/C
sickle-cell anemia, conducted at the Yolo Sud SS Joint Medical Center in St.
Crispin in Kinshasa and Jason Sendwe Hospital in Lubumbashi, from 2015 to 2016. HIV seroprevalence of 505 subjects
homozygous sickle cell Duffy-46C/C was established by
Immuno-chromatography tests determined HIV1/2 test Uni-Gold to determine the
anti-HIV antibodies. CD4
rate was also determined and plasma viral load. We collected 505 samples of
blood from sickle cell anemia aged from 1 year to 65 years (mean age 15.6
years) with 235 subjects male and 270 female subjects. A positive serology was
found in 6 cases (1.19%), including 5 female subjects of which 4 cases had
received 1-5 transfusions and 2 cases
were vaso-occlusive crisis (VOC). Viral load was determined, and 4 individuals were
detectable and 2 were undetectable. Their CD4 levels were raised to more than 500 c/μL, ranging between 543 to 893 c/μl. The blood transfusion remains a risk in the
transmission of HIV/AIDS among people polytransfusees, due probably to the
window door. We will have to strengthen blood safety by equipping laboratories
and blood banks with reliable early tests that detect viral RNA of HIV.
Cite this paper
Anzwal, P. L. , Kalumba, A. K. , Mwamba, J. K. , Sentob, S. S. , Tuma, H. S. N. and Balaka, E. M. (2017). Seroprevalence Virus in Human Immunodeficiency Sickle Cell Anemia Duffy-46C/C in Democratic Republic of Congo—Case of the City of Kinshasa and Lubumbashi. Open Access Library Journal, 4, e3697. doi: http://dx.doi.org/10.4236/oalib.1103697.
Tshilolo, L., Aissi, L.M., Lukusa, D., Kinsiama, C., Wembonyama, S., Gulbis, B. and Vertongen, F. (2009) Neonatal Screening for Sickle Cell Anemia in the Democratic Republic of Congo: Experience from a Pioneer Project Is 31204 Newborns. Journal of Clinical Pathology, 62, 35-38.
Ngaly, B., Kayembe, K., Mann, J., Ryder, R., Mbensa, M. and Francis, H. (1987) The Infection among Children with Sickle Cell Anemia, Abstract III. International Conference on AIDS, Washington DC, 1-5 June.
Tshilolo, L., Wembonyama, S., Ekwalanga, M., Ngasia, B., Gonzalez, J.P., Wheat Ondo, I. and Wamba, G. (2010) Sickle Cell Disease in DRC Congo and Central Africa a Century after-James B. Herrick. India.
Nouraie, M., Nekhai, S. and Gordeuk, V.R. (2012) Sickle Cell Disease Is Associated with Decreased HIV HBV and HCV Goal Higher Co Morbidities in US Hospital Discharge Records: A Cross-Sectional Study. Sexually Transmitted Infections, 88, 528-533.
https://doi.org/10.1136/sextrans-2011-050459
Diarra, A.B., Guindo, A., Kouriba, B., Dorie, A., Diabaté, D.T., Diawara, I.F., Fan, é. B., Toure, B.A., Traoré, A., Gulbis, B. and Diallo, D.A. (2013) Sickle Cell Anemia and Transfusion Safety in Bamako, Mali. Seroprevalence of HIV, HBV and HCV Infections and Alloimmunization Belonged to Rh and Kell Systems in Sickle Cell Anemia Patients. Elsevier Masson SAS.
Lukuni, L., Binda, P., Mbensa, L. and Binda, K.M. (1989) Seroprevalence and Clinical and Biological Manifestation of AIDS in the Sickle Cell Child Department of Pediatrics, UNIKIN.
Neto, J.P., Lyra, I.M., Reis, M.G., et al. (2011) The Combination of Infection and Clinical Severity in Sickle Cell Anemia Patients. Transactions of the Royal Society of Tropical Medicine and Hygiene, 105, 121-126.
https://doi.org/10.1016/j.trstmh.2010.11.007
Tshilolo, L., Wembonyama, S., Ngasia, B., Kazadi, G., Ekwalanga, Mr., Sica, L., Wamba, G. and Gonzalez, J.P. (2012) Burden of Sickle Cell Disease in Central Africa: Morbidity and Causes of Mortality. Atlanta.
Obaro, S. (2012) Does Sickle Cell Disease Protect against HIV/AIDS? Correspondence to Dr. Stephen Obaro, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA; Published Online First 20 June.
Ngo, S., Eboumbou, C., Ngouadjeu, E., Zouhairatou, H. and Mbanya, D. (2013) Prevalence of HIV Seropositivity among Sickle Cell Disease Patients at the Yaounde Central Hospital. Health Science, 14.
Bagasra, O., Steiner, R.M., Castro, S.K.B.O., Dornadula, G., Embury, S., Jungkind, D., Kutlar, L.B.A. and Burchott, S. (1998) Viral Burden and Disease Progression in HIV-1-Infected Patients with Sickle Cell Anemia. American Journal of Hematology, 59, 199-207.