Background:
In our case we discussed the sedation made with dexmedeto-midine
unresponsiveness and exaggerated response to propofol of
patients with essential tremor. Case: 75
years old, male, without any co-existing disease, with essential tremor
patient, planned deep brain stimulation operation under sedoanalgesia,
one week before the operation the patient evaluated and was planned to perform
brain magnetic resonance imaging (MRI)
under sedationin the MRI unit. We
performed sedation with fractional doses of 20 mg propofol than maintained the
propofol infusion 0.5-1 mg/kg/hour. At the 20th minute the propofol infusion was stopped on the
dropped of the patient’s blood pressure at 50/35 mmHg. After 20 mg efedrin was given
intravenously, blood pressure was achieved to the basal levels in one minute.
One week after we performed MRI and we gave only half dose of first time. Sleeping pattern analysis
for obstructive sleep apnea or sleeping disorders was done for this patient. On the DBS day we
decided to perform the procedure with dexmedetomidine. Initial
bispectral index values 98%-99% (BIS aspect). After 20 minute neither
BIS values, nor Ramsey changes. We maintained high doses dexmedetomidine but it didn’t
worked, so we turned to propofol on 30th minute and after we performed
10 mg propofol, BIS values was 85% - 88%
throughout the operation. We gave 40-50 mg propofol totally throughout the procedure and RSS was 3-4. Discussion: Unresponsiveness of dexmedetomidine that we faced in our
case may be by neurodegeneration of locus coeruleus and we could explain this exaggerated response to propofol
of this patient on GABA receptor increased intensity.
Cite this paper
Yorulmazi, I. S. , Esbah, A. U. , Dikici, S. , Ozlu, O. and Er, U. (2017). Unanswered Response to Dexmedetomidine and Exaggerated Response to Propofol during Deep Brain Stimulation in Essential Tremor Case. Open Access Library Journal, 4, e3605. doi: http://dx.doi.org/10.4236/oalib.1103605.
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