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Significance of Initial Maternal Hemoglobin Concentration during Pregnancy in Birth Weight and Preterm Delivery in Sri Lanka

DOI: 10.4236/oalib.1102725, PP. 1-8

Subject Areas: Public Health

Keywords: Anemia, Hemoglobin Concentration, Low Birth Weight, Preterm Delivery, Relative Risk

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Abstract

Objective: The study was conducted to investigate the influence of initial hemoglobin (Hb) concentration of Sri Lankan pregnant mothers on baby’s birth weight and preterm delivery. Methods: For this retrospective study, 3867 primigravid pregnant women in Sri Lanka were followed till they deliver the baby. Sampling method was cluster sampling where all the pregnant mothers giving singleton birth in the selected 15 health division were followed for three years. Mothers’ initial Hb concentration, weight gain during the pregnancy and neonatal outcomes were assessed. Results: Severe iron deficiency anemia at the initial stage of pregnancy had 3.9 - 14.4 folder higher relative risk of low birth weight (LBW) and 3.0 - 8.1 folder higher relative risk of preterm delivery at 95% confidence interval. The minimum incidence of preterm delivery and maximum weight gain of mothers occurs in association with an initial Hb concentration of 105 - 125 g/L. Conclusion: The excess level of initial iron content at pregnancy does not contribute for any adverse effect on pregnancy outcome as like in the later part of pregnancy and therefore supplement of iron during the initial pregnancy for mothers can be carried out regardless of whether the mother is anemic.

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Razmy, A. M. (2016). Significance of Initial Maternal Hemoglobin Concentration during Pregnancy in Birth Weight and Preterm Delivery in Sri Lanka. Open Access Library Journal, 3, e2725. doi: http://dx.doi.org/10.4236/oalib.1102725.

References

[1]  World Health Organization (2013) The Prevalence of Anaemia in Women: A Tabulation of Available Information WHO/MCH/MSM/92.2. 2nd Edition.
[2]  Steer, P. (2000) Maternal Hemoglobin Concentration and Birth Weight. American Journal of Clinical Nutrition, 71, 1285S-1287S.
[3]  Cyril, C.D. (2007) The Prevalence of Anemia among Pregnant Women at Booking in Enugu, South Eastern Nigeria. Medscape General Medicine, 9, 11.
[4]  Scholl, T.O. and Hediger, M.L. (1994) Anemia and Iron-Deficiency Anemia: Compilation of Data on Pregnancy Outcome. American Journal of Clinical Nutrition, 59, 492S-500S.
[5]  Mahomed, K. (2000) Iron and Folate Supplementation in Pregnancy. Cochrane Database of Systematic Reviews, 2000, CD001135.
[6]  Nyuke, R.B. and Letsky, E.A. (2000) Etiology of Anemia in Pregnancy in South Malawi. American Journal of Clinical Nutrition, 72, 247-256.
[7]  World Health Organization (2012) International Classification of Diseases and Related Health Problems. 10th Revision.
[8]  Huddy, C.L., Johnson, A. and Hope, P.L. (2001) Educational and Behavioral Problems in Babies of 32 - 35 Weeks Gestation. Archives of Disease in Childhood. Fetal and Neonatal Edition, 85, 23-28.
https://doi.org/10.1136/fn.85.1.F23
[9]  Wang, M.L., Dorer, D.J., Fleming, M.P. and Catlin, E.A. (2004) Clinical Outcomes of Near- Term Infants. Pediatrics, 114, 372-376.
https://doi.org/10.1542/peds.114.2.372
[10]  Lindsay, H.A. (2000) Anemia and Iron Deficiency: Effects on Pregnancy Outcome. American Journal of Clinical Nutrition, 71, 1280-1284.
[11]  Murphy, J.F., O’Riordan, J., Newcombe, R.J., Coles, E.C. and Pearson, J.F. (1986) Relation of Hemoglobin Levels in First and Second Trimesters to Outcome of Pregnancy. Lancet, 1, 992-995.
https://doi.org/10.1016/S0140-6736(86)91269-9
[12]  Hemminki, E. and Rimpela, U. (1991) Iron Supplementation, Maternal Packed Cell Volume, and Fetal Growth. Archives of Disease in Childhood, 66, 422-425.
https://doi.org/10.1136/adc.66.4_Spec_No.422
[13]  Agarwal, K.N., Agarwal, D.K. and Mishra, K.P. (1991) Impact of Anemia Prophylaxis in Pregnancy on Maternal Hemoglobin, Serum Ferritin and Birth Weight. Indian Journal of Medical Research, 94, 277-280.
[14]  Singla, P.N., Tyagi, M., Kumar, A., Dash, D. and Shankar, R. (1997) Fetal Growth in Maternal Anemia. Journal of Tropical Pediatrics, 43, 89-92.
https://doi.org/10.1093/tropej/43.2.89
[15]  Yip, R. (2000) Significance of an Abnormally Low or High Hemoglobin Concentration during Pregnancy: Special Consideration of Iron Nutrition. American Journal of Clinical Nutrition, 72, 272-279.
[16]  Steer, P.J. (2000) Maternal Hemoglobin Concentration and Birth Weight. American Journal of Clinical Nutrition, 71, 1285S-1287S.
[17]  Garn, S.M., Ridella, S.A., Tetzold, A.S. and Falkner, F. (1981) Maternal Hematological Levels and Pregnancy Outcomes. Seminars in Perinatology, 5, 155-162.
[18]  Steer, P., Alam, M.A., Wadsworth, J. and Welch, A. (1995) Relation between Maternal Haemoglobin Concentration and Birth Weight in Different Ethnic Groups. BMJ, 310, 489- 491.
https://doi.org/10.1136/bmj.310.6978.489
[19]  Hirve, S.S. and Ganatra, B.R. (1994) Determinants of Low Birth Weight: A Community Based Prospective Cohort Study. Indian Pediatrics, 10, 1221-1225.
[20]  Goldenberg, R.L., Tamura, T., DuBard, M., Johnston, K.E., Copper, R.L. and Neggers, Y. (1996) Plasma Ferritin and Pregnancy Outcome. American Journal of Obstetrics and Gynecology, 175, 1356-1359.
https://doi.org/10.1016/S0002-9378(96)70054-6
[21]  Tamura, T., Goldenberg, R.L., Johnston, K.E., Cliver, S.P. and Hickey, C.A. (1996) Serum Ferritin: A Predictor of Early Spontaneous Preterm Delivery. Obstetrics & Gynecolog, 87, 360-365.
https://doi.org/10.1016/0029-7844(95)00437-8
[22]  Rondo, P.H., Abbott, R., Rodrigues, L.C. and Tomkins, A.M. (1997) The Influence of Maternal Nutritional Factors on Intrauterine Growth Retardation in Brazil. Paediatric and Perinatal Epidemiology, 11, 152-166.
https://doi.org/10.1046/j.1365-3016.1997.d01-16.x
[23]  Murphy, J.F., O’Riordan, J., Newcombe, R.J., Coles, E.C. and Pearson, J.F. (1986) Relation of Hemoglobin Levels in First and Second Trimesters to Outcome of Pregnancy. Lancet, 1, 992-995.
https://doi.org/10.1016/S0140-6736(86)91269-9
[24]  Scholl, T.O., Hediger, M.L., Fischer, R.L. and Shearer, J.W. (1992) Anemia vs Iron Deficiency: Increased Risk of Preterm Delivery in a Prospective Study. American Journal of Clinical Nutrition, 55, 985-988.
[25]  Hemminki, E. and Starfield, B. (1978) Routine Administration of Iron and Vitamins during Pregnancy: Review of Controlled Clinical Trials. British Journal of Obstetrics and Gynaecology, 85, 404-410.
https://doi.org/10.1111/j.1471-0528.1978.tb14905.x

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