全部 标题 作者
关键词 摘要


Amyotrophic Lateral Sclerosis (ALS) about 2 Observations in the Neurology Department of the University Hospital of Cocody

DOI: 10.4236/oalib.1101924, PP. 1-6

Subject Areas: Neurology

Keywords: Diagnosis, ALS, Support

Full-Text   Cite this paper   Add to My Lib

Abstract

Amyotrophic lateral sclerosis (ALS) is a rare but serious neurodegenerative disease characterized by progressive muscular paralysis without overall achievement of higher functions, resulting from motor neuron destruction. The present study reports two cases of elderly female patients aged 45 and 54 years, respectively, allowed for a progressive motor deficit of 4 members. Neurological examination found a spastic pyramidal syndrome and a neurogenic syndrome device of 4 members without sensory syndrome. The ENMG revealed a pure motor neurogenic compatible with involvement of the anterior horn of the spinal cord, holding the ALS diagnosis. The standard radiography and cervical MRI were normal. These patients received analgesics, nursing, physiotherapy and psychotherapy. Then they were lost. ALS is a rare disease (incidence: 1.25%). Our patients, with a mean age of 54.5 years, showed clinical and laboratory signs associated with them classically encountered. The diagnosis is suspected in a spastic pyramidal syndrome and neurogenic peripheral syndrome of 4 members but not eliminate cervical spondylotic myelopathy one. The ENMG confirms it. Although the treatment is disappointing, it’s based on the riluzole and palliative care, but the evolution is inexorably toward death.

Cite this paper

Yapo-Ehounoud, C. , Aka-Anghui-Diarra, E. , Amon-Tanoh, M. , Assi, B. , Kouame-Assouan, A. , Tanoh, C. and Kotchi, E. B. (2015). Amyotrophic Lateral Sclerosis (ALS) about 2 Observations in the Neurology Department of the University Hospital of Cocody. Open Access Library Journal, 2, e1924. doi: http://dx.doi.org/10.4236/oalib.1101924.

References

[1]  (2008) General Public Orphanet Encyclopedia. Amyotrophic Lateral Sclerosis. Mai.
https://www.orpha.net/data/patho/Pub/fr/Sclerose
LateraleAmyotrophique-FRfrPub106.pdf/

[2]  Leif Sigurdson, A. (2011) Amyotrophic Lateral Sclerosis Presenting as Upper Limb Weakness in a 35 Years Old Female: A Case Report. Journal of the Canadian Chiropractic Association, 55, 204-210.
[3]  Marin, P.C.B., Nicol, G.L.M. and Preux, P.-M. (2014) Epidemiology, Clinical Spectrum of ALS and Differential Diagnoses. La Presse Médicale, 43, 538-548.
www.em-consulte.com/revue/lpm
www.sciencedirect.com
[4]  Lee, J.R., Annegers, J.F. and Call, S.H. (1995) Prognosis of Amyotrophic Lateral Sclerosis and the Effect of Referral Selection. Journal of the Neurological Sciences, 132, 207-215.
http://dx.doi.org/10.1016/0022-510X(95)00154-T
[5]  Fischer, L.R., et al. (2004) Amyotrophic Lateral Sclerosis Is a Distal Axonopathy: Evidence in Mice and Man. Experimental Neurology, 185, 232-240.
http://dx.doi.org/10.1016/j.expneurol.2003.10.004
[6]  Bresch, S., Delmont, E., Soriani, M.H. and Desnuelle, C. (2014) Contribution of Electromyography in the Early Diagnosis of ALS to Bulbar Onset: Comparison of El Escorial Criteria, Modified El Escorial and Awaji. Neurological Review, 170, 134-139.
www.sciencedirect.com
[7]  Traynor, B.J., et al. (2000) Clinical Features of Amyotrophic Lateral Sclerosis Selon El Escorial and the Airlie House Diagnostic Criteria: A Population Based Study. Archives of Neurology, 57, 1171-1176.
http://dx.doi.org/10.1001/archneur.57.8.1171
[8]  Juliette, S., Choumert, A., Vandenberghe, N., Gervais, H.B., Bouhour, F. and Vial, E.B.C. (2003) Diagnosis of Amyotrophic Lateral Sclerosis (ALS) through Excess: Experience of ALS Center of Lyon about 18 Patients. Summary of JNLF Montpellier.
[9]  Bensimon, G., et al. (1994) A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis. ALS/Riluzole Study Group. New England Journal of Medicine, 330, 585-591.
http://dx.doi.org/10.1056/NEJM199403033300901
[10]  Pradat, P.F., et al. (2009) News in Basic and Clinical Research on ALS. Revue Neurologique (Paris).
[11]  Pringle, E.C., et al. (1992) Primary Lateral Sclerosis. Clinical Features, Neuropathology and Diagnostic Criteria. Brain, 115, 495-520.
http://dx.doi.org/10.1093/brain/115.2.495
[12]  Pradat, P.F., et al. (2006) What Are the Differential Diagnoses and Forms Borders of ALS? Revue Neurologique (Paris), 162, S81-S90.
http://dx.doi.org/10.1016/S0035-3787(06)75168-2

Full-Text


comments powered by Disqus